Spotlight – The Struggle to Find a Cancer Vaccine Continues

Spotlight – The Struggle to Find a Cancer Vaccine Continues

With the exception of the HPV vaccine, which is a preventative rather than a therapeutic vaccine, most attempts at formulating a cancer vaccine have fallen flat. Most of the earliest cancer vaccines focused on bolstering the immune system to protect against cancer growth in the body. Sometimes, these vaccines did invoke a strong immune response,… Read More…

Immune Activation Advances Hold Promise for Immuno-Oncology

Immune Activation Advances Hold Promise for Immuno-Oncology

Immuno-oncology has largely changed the landscape of cancer care, but a number of challenges still exist. From judging efficacy to understanding why some people react to the treatment while others do not, researchers are tackling a number of issues. One young startup in Europe is attempting to address the latter question. At present, only about… Read More…

Scientists Consider Using New Animal Models for Immuno-Oncology Research

Scientists Consider Using New Animal Models for Immuno-Oncology Research

Oncological researchers face a major hurdle in trying to model the complexity of the disease, which has led to genetically engineered rats and, most recently, humanized rat models for use in preclinical studies. Scientists have achieved this unique humanized model using a range of genetic engineering technologies, including transcription activator-like effector nucleases (TALENs) and clustered… Read More…

What You Need to Know about Genetic Engineering and Cancer Immunotherapy

What You Need to Know about Genetic Engineering and Cancer Immunotherapy

The biomedical world was revolutionized by the introduction of clustered regularly interspaced short palindromic repeats (CRISPR) gene-editing technology, which may soon have cancer immunotherapeutic applications. Human trials of the technology are drawing nearer, as an advisory committee at the National Institutes of Health recently approved a proposal that would use CRISPR-Cas9 to bolster cancer immunotherapies… Read More…

The Potential of Oncolytic Virotherapy in Oncology and Immunotherapy

The Potential of Oncolytic Virotherapy in Oncology and Immunotherapy

One of the newest and most exciting approaches to immuno-oncology is oncolytic virotherapy. In recent years, an increasing number of researchers have begun experimenting with oncolytic virotherapy and its immunotherapeutic applications. The connection between cancer suppression and viruses was first noted in the mid-20th century, but the connection wasn’t further analyzed until recently, under the… Read More…

Is This New Approach the Future of Cancer Care?

Is This New Approach the Future of Cancer Care?

Immuno-oncology promises to destroy both primary and metastatic tumors using an immune-based response. Even more exciting is the possibility of building tumor-specific immunological memory, which means that the body will actually build immunity toward future tumor cells, thus resulting in a lasting remission. By using the body’s own immune systems, oncologists can avoid much of… Read More…

Setbacks on the Path to CAR T Cell Therapy Approval

Setbacks on the Path to CAR T Cell Therapy Approval

Many scientists, physicians, and patients are looking to immuno-oncology as the future of cancer treatment, especially with cutting-edge immunotherapeutic techniques like chimeric antigen receptor (CAR) T cell therapy, which has been called a “living drug.” This phrase refers to the fact that the therapy is derived from the patient’s own living cells. The treatment begins… Read More…

How Does Your Immune System Protect You?

How Does Your Immune System Protect You?

In recent years, immuno-oncology has received a lot of hype and praise because of some high-profile success cases, such as former president Jimmy Carter, and investments from popular culture icons like Sean Parker. What makes immunotherapy such an exciting option for the field of oncology is that it bolsters the body’s natural immunity to disease.… Read More…