Category Archives: Disease

Spotlight – The Struggle to Find a Cancer Vaccine Continues

Spotlight – The Struggle to Find a Cancer Vaccine Continues

With the exception of the HPV vaccine, which is a preventative rather than a therapeutic vaccine, most attempts at formulating a cancer vaccine have fallen flat. Most of the earliest cancer vaccines focused on bolstering the immune system to protect against cancer growth in the body. Sometimes, these vaccines did invoke a strong immune response,… Read More…

Scientists Consider Using New Animal Models for Immuno-Oncology Research

Scientists Consider Using New Animal Models for Immuno-Oncology Research

Oncological researchers face a major hurdle in trying to model the complexity of the disease, which has led to genetically engineered rats and, most recently, humanized rat models for use in preclinical studies. Scientists have achieved this unique humanized model using a range of genetic engineering technologies, including transcription activator-like effector nucleases (TALENs) and clustered… Read More…

What You Need to Know about Genetic Engineering and Cancer Immunotherapy

What You Need to Know about Genetic Engineering and Cancer Immunotherapy

The biomedical world was revolutionized by the introduction of clustered regularly interspaced short palindromic repeats (CRISPR) gene-editing technology, which may soon have cancer immunotherapeutic applications. Human trials of the technology are drawing nearer, as an advisory committee at the National Institutes of Health recently approved a proposal that would use CRISPR-Cas9 to bolster cancer immunotherapies… Read More…

Is This New Approach the Future of Cancer Care?

Is This New Approach the Future of Cancer Care?

Immuno-oncology promises to destroy both primary and metastatic tumors using an immune-based response. Even more exciting is the possibility of building tumor-specific immunological memory, which means that the body will actually build immunity toward future tumor cells, thus resulting in a lasting remission. By using the body’s own immune systems, oncologists can avoid much of… Read More…

Amazing New Drug Shows Strong Promise for Multiple Tumor Types

Amazing New Drug Shows Strong Promise for Multiple Tumor Types

Recently, BeiGene presented the preliminary findings of an ongoing dose-escalation Phase I study of BGB-A317, a checkpoint inhibitor. The presentation was made at the 2016 Annual Meeting of the American Society of Clinical Oncology in Chicago. BGB-A317, a monoclonal antibody, is designed to bind to PD-1, a receptor on the surface of cells that downregulates… Read More…

Immuno-Oncology Research: The Need to Stand Out in the Crowd

Immuno-Oncology Research: The Need to Stand Out in the Crowd

Immuno-oncology has become a central focus for medical research firms and organizations across the country, and many are working on the same targets. Over the past five years, interest in immuno-oncology has spiked dramatically due to real changes in survival curves for many cancers and the extraordinary amount of money being made available. While all… Read More…

Immuno-Oncology – What Do People Want to Know?

Immuno-Oncology – What Do People Want to Know?

Cancer immunotherapy is a field that has seen remarkable growth in the past decade. This growth is largely driven by some incredible stories of success. While immuno-oncology’s potential to provide treatments for even the most intractable cancers is high, a number of questions still exist, from exactly how to apply insights in the clinical setting… Read More…