Category Archives: Treatments

Immune Activation Advances Hold Promise for Immuno-Oncology

Immune Activation Advances Hold Promise for Immuno-Oncology

Immuno-oncology has largely changed the landscape of cancer care, but a number of challenges still exist. From judging efficacy to understanding why some people react to the treatment while others do not, researchers are tackling a number of issues. One young startup in Europe is attempting to address the latter question. At present, only about… Read More…

Scientists Consider Using New Animal Models for Immuno-Oncology Research

Scientists Consider Using New Animal Models for Immuno-Oncology Research

Oncological researchers face a major hurdle in trying to model the complexity of the disease, which has led to genetically engineered rats and, most recently, humanized rat models for use in preclinical studies. Scientists have achieved this unique humanized model using a range of genetic engineering technologies, including transcription activator-like effector nucleases (TALENs) and clustered… Read More…

What You Need to Know about Genetic Engineering and Cancer Immunotherapy

What You Need to Know about Genetic Engineering and Cancer Immunotherapy

The biomedical world was revolutionized by the introduction of clustered regularly interspaced short palindromic repeats (CRISPR) gene-editing technology, which may soon have cancer immunotherapeutic applications. Human trials of the technology are drawing nearer, as an advisory committee at the National Institutes of Health recently approved a proposal that would use CRISPR-Cas9 to bolster cancer immunotherapies… Read More…

Is This New Approach the Future of Cancer Care?

Is This New Approach the Future of Cancer Care?

Immuno-oncology promises to destroy both primary and metastatic tumors using an immune-based response. Even more exciting is the possibility of building tumor-specific immunological memory, which means that the body will actually build immunity toward future tumor cells, thus resulting in a lasting remission. By using the body’s own immune systems, oncologists can avoid much of… Read More…

Setbacks on the Path to CAR T Cell Therapy Approval

Setbacks on the Path to CAR T Cell Therapy Approval

Many scientists, physicians, and patients are looking to immuno-oncology as the future of cancer treatment, especially with cutting-edge immunotherapeutic techniques like chimeric antigen receptor (CAR) T cell therapy, which has been called a “living drug.” This phrase refers to the fact that the therapy is derived from the patient’s own living cells. The treatment begins… Read More…

Amazing New Drug Shows Strong Promise for Multiple Tumor Types

Amazing New Drug Shows Strong Promise for Multiple Tumor Types

Recently, BeiGene presented the preliminary findings of an ongoing dose-escalation Phase I study of BGB-A317, a checkpoint inhibitor. The presentation was made at the 2016 Annual Meeting of the American Society of Clinical Oncology in Chicago. BGB-A317, a monoclonal antibody, is designed to bind to PD-1, a receptor on the surface of cells that downregulates… Read More…

What You Need to Know about Cytokines in Immuno-Oncology

What You Need to Know about Cytokines in Immuno-Oncology

One of the main approaches to cancer immunotherapy involves cytokines, which serve as messengers for the immune system. Immune cells secrete cytokines, which are proteins or glycoproteins, to strengthen or suppress normal immune functions. Researchers are attempting to take advantage of this regulatory role to boost the activity of macrophages and natural killer cells, as… Read More…

CAR T-Cell Therapy: Engineering Your Immune Cells to Fight Cancer

CAR T-Cell Therapy: Engineering Your Immune Cells to Fight Cancer

One of the most important questions that immuno-oncologists will tackle in the coming years is figuring out where chimeric antigen receptor (CAR) T-cell therapy will fit into the larger picture. Academic centers across the country have been using this technology to successfully treat patients, but adapting this complicated system to a community setting introduces a… Read More…

A Look at the Role Monoclonal Antibodies Play in Immuno-Oncology

A Look at the Role Monoclonal Antibodies Play in Immuno-Oncology

Immuno-oncological research is exploring several different approaches to immunotherapy, including vaccines, checkpoint inhibitors, and monoclonal antibodies. At present, several different types of monoclonal antibody drugs exist, but researchers are still exploring how to employ them most effectively in a treatment plan. The term monoclonal antibody refers to a molecule produced in a laboratory that has… Read More…